Catch the vibe on I-65! Follow this lesser-known road trip through the heart of the Midwestern and Southeastern USA. You’ll drive from the shores of Lake Michigan to Gulf beaches, stopping along the way to explore big cities, bourbon country, legendary music scenes, historic districts – and a truly unique slice of Americana.

Plan Your I-65 Drive

Browse the map below to learn about the states and cities along the route.

Regions States U.S. Territories
  • Southeast

  • Midwest

Major International Airports

Highlights of the Route

Chicago, Illinois

  • Take a boat cruise for skyline views, follow the lakefront trail and relax on beaches tucked among 41 kilometers of shoreline.

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  • Marvel at Lake Michigan and Chicago’s famed architecture from the Sky Deck at Willis Tower or 360 CHICAGO at 875 North Michigan Avenue, formerly the Hancock Building.

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  • From the Museum Campus to Navy Pier, Chicago’s lakefront beckons with endless fun.

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Louisville, Kentucky

  • Witness the Kentucky Derby, or tour the grounds and visit the museum year-round.

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  • Find interactive exhibits honoring the famed boxer, Louisville’s greatest champion and humanitarian.

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  • Check out the distilleries, tasting rooms, bars and restaurants of this revitalized downtown historic district.

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Nashville, Tennessee

  • See music night and day at 250-plus venues – from the Grand Ole Opry and Bluebird Cafe to the festive scene of Lower Broadway.

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  • The city is home to more music museums than anywhere in the world celebrating an array of genres, musicians and cultures.

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  • Try Southern staples, hot chicken, chef-driven menus and three MICHELIN-starred restaurants, and enjoy foodie walking tours and hands-on classes.

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Franklin, Tennessee

  • Browse antique stores, enjoy top restaurants and stroll cobblestone streets.

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  • Dive into local history at Civil War landmarks, battlefields and artifact-filled historic sites.

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  • Drink craft whiskey, taste farm-fresh produce and dine at idyllic eateries.

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Huntsville, Alabama

  • The largest spaceflight museum on Earth captivates with real rockets and hands-on fun.

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  • Wander among vibrant blooms, lush foliage and the USA’s largest open-air butterfly house.

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  • This former textile mill houses public artist studios and hosts live performances and creative classes.

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Florence & Muscle Shoals, Alabama

  • Take a tour of the region’s first studio, where the “Muscle Shoals Sound” was created.

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  • Studio musicians from FAME founded this legendary recording palace, where many music icons recorded.

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  • Visit Ivy Green, where writer and disability activist Helen Keller was born.

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Birmingham, Alabama

  • See the world’s largest collection of motorcycles, plus rare classic cars and an on-site racetrack.

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  • Learn about turning points in the Civil Rights Movement at educational centers, landmarks and historic sites.

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  • Play acclaimed courses on the Robert Trent Jones Golf Trail including Ross Bridge Resort and Oxmoor Valley.

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Montgomery, Alabama

  • See powerful exhibits at the Equal Justice Initiative’s Legacy Museum, National Memorial for Peace and Justice, and Freedom Monument Sculpture Park.

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  • Learn about the brave woman who sparked the Montgomery Bus Boycott.

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  • Walk to museums, restaurants, shops and entertainment including live music, baseball and river cruises.

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Mobile, Alabama

  • Celebrate Mardi Gras in its North American birthplace or visit the Mobile Carnival Museum.

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  • A number of compelling sites and museums trace Mobile’s past, present and future.

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  • Stroll historic districts to discover cosmopolitan restaurants, lively bars and local eateries offering a variety of cuisine.

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Alabama’s Gulf Coast

  • Delight in blue skies, soft sands, gentle breezes and turquoise waters on 51 kilometers of pristine shoreline.

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  • Indulge in Gulf seafood in low-key spots with a backdrop of ocean waves and live music.

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  • From parasailing and paddling to boat and fishing charters, ways to explore the water abound here.

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New Orleans, Louisiana

  • Among festive street scenes, see iconic iron balconies and dance at jazz clubs in the city’s oldest neighborhood.

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  • Walk this bustling corridor to listen to jazz, blues and reggae in famed music venues every night.

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  • Just outside the city, take an exciting ride on an airboat or paddle serene bayous.

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Star Attractions

Friends enjoying the Chicago, Illinois, lakefront

Drive I-65